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. Author manuscript; available in PMC: 2011 Oct 12.
Published in final edited form as: Org Lett. 2009 Feb 19;11(4):943–946. doi: 10.1021/ol802930q

Table 3.

Scope of HNR1R2 in enantioselective synthesis of (R)-β-fluoroamines.

graphic file with name nihms91352t9.jpg
compda product yield (%)b ee (%)c
8a graphic file with name nihms91352t10.jpg 70 >98 (R)
8b graphic file with name nihms91352t11.jpg 80 >87 (R)
8c graphic file with name nihms91352t12.jpg 76 >98 (R)
8d graphic file with name nihms91352t13.jpg 69 >94 (R)
8e graphic file with name nihms91352t14.jpg 65 >96 (R)
a

All reactions were performed on a 0.05 mmol scale and proceeded to complete conversion.

b

Yield after chromatography.

c

Enantiomeric excess were determinedd using chiral stationary phase HPLC..

See Supporting Information for more details.