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One-pot β-fluoroamine synthesis via organocatalysis
 | |||||
|---|---|---|---|---|---|
| entrya | solvent | temp (°C) |
time (h) |
yield (%)c |
ee (%)b |
| 1 | THF | 24 | 3 | 45 | >95 |
| 2 | CH3CN | 24 | 3 | 36 | >95 |
| 3 | CH2Cl2 | 24 | 24 | 12 | ndd |
| 4 | DCE | 24 | 24 | 0 | ndd |
| 5 | THF/i-PrOH | −20 | 3 | 65 | >96 |
All reactions were performed on a 0.05 mmol scale.
Enantiomeric excess were determined using chiral stationary phase HPLC.
Yield after chromatography.
Not determined.
