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IC50 values for a series of para-toluenesulfonyl X analogues of inhibitor 27 h in whole-cell viability studies.
 | ||||
|---|---|---|---|---|
| Compd | X | IC50 [µm] | ||
| MDA-MB-468[a] | OCI-AML-2[b] | DU145[c] | ||
| 27 h | NCH3 | 17 ± 4 | 37 ± 12 | 36 ± 13 |
| 41 | NH | 21 ± 6 | 38 ± 14 | 33 ± 8 |
| 43 | NBoc | 10 ± 9 | 24 ± 16 | 18 ± 9 |
| 46 | O | 43 ± 6 | 52 ± 13 | 62 ± 12 |
MDA-MB-468: breast cancer.
OCI-AML-2: acute myeloid leukemia.
DU145: prostate cancer.
