Table 3.
EMSA inhibition data for disruption of the Stat3–Stat3:DNA complex in vitro by a series of R1=N-(4-piperidinyl)methyl-based analogues of compound 10.
 | ||
|---|---|---|
| Compd | R3 | IC50 [µm] |
| 27 ja | H | > 300 |
| 27 jb |  |
> 300 |
| 27 jc |  |
> 300 |
| 27 jd |  |
> 300 |
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