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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: ChemMedChem. 2011 May 25;6(8):1459–1470. doi: 10.1002/cmdc.201100194

Table 4.

EMSA inhibition data for disruption of the Stat3–Stat3:DNA complex in vitro by a series of R1=N-(4-piperidinyl)benzyl-based analogues of compound 10.

graphic file with name nihms326591t21.jpg
Compd R3 IC50 [µm] Compd R3 IC50 [µm]
27 ka graphic file with name nihms326591t22.jpg > 300 27 kf graphic file with name nihms326591t23.jpg > 300
27 kb  H > 300 27 kg graphic file with name nihms326591t24.jpg     50 ± 15
27 kc graphic file with name nihms326591t25.jpg > 300 27 kah graphic file with name nihms326591t26.jpg > 300
27 kd graphic file with name nihms326591t27.jpg     45 ± 12 27 ki graphic file with name nihms326591t28.jpg > 300
27 ke graphic file with name nihms326591t29.jpg > 300