Table 5.

EMSA inhibition data for disruption of the Stat3–Stat3:DNA complex in vitro by a series of biphenyl- and terphenyl-based derivatives of inhibitor 27 a.

Compd	R4	IC50 [µm]	Compd	R4	IC50 [µm]
27 g		115 ± 760	27 na		63 ± 2
27 la		191 ± 8	27 nb		> 300
27 lb		250 ± 23	27 nc		82 ± 1
27 lc		> 300	27 nd		90
27 gld		141 ± 10	27 ne		97 ± 17
27 le		> 300	27 nf		> 300
27 lf		274 ± 10	27 ng		74 ± 9
27 lg		> 300	27 nh		43 ± 1.3