Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: ChemMedChem. 2011 May 25;6(8):1459–1470. doi: 10.1002/cmdc.201100194

Table 7.

EMSA and FP inhibition data of selected inhibitors for disruption of the Stat3–Stat3:DNA and Stat3–gp130 sequence complexes in vitro.

graphic file with name nihms326591t49.jpg
Compd R1 X R2 EMSA IC50 [µm] FP Ki [µm]
8 (S3I-201)  H O graphic file with name nihms326591t50.jpg 86 ± 33 > 50
27 h graphic file with name nihms326591t51.jpg NCH3 graphic file with name nihms326591t52.jpg 35 ± 9   15 ± 4.9
27 kd graphic file with name nihms326591t53.jpg NCH3 graphic file with name nihms326591t54.jpg 45 ± 12   18.7 ± 1.4
27 kd graphic file with name nihms326591t55.jpg NCH3 graphic file with name nihms326591t56.jpg 50 ± 15   21.5 ± 2.2
27 kd graphic file with name nihms326591t57.jpg NCH3 graphic file with name nihms326591t58.jpg 74.3 ± 9.3   21.6 ± 0.9
27 kd graphic file with name nihms326591t59.jpg NCH3 graphic file with name nihms326591t60.jpg 43 ± 1.3   16.7 ± 1.7