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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: ChemMedChem. 2011 May 25;6(8):1459–1470. doi: 10.1002/cmdc.201100194

Table 9.

IC50 values for selected R1-substituted analogues in whole-cell viability studies.

graphic file with name nihms326591t61.jpg
Compd R1 IC50 [µm]
MDA-MB-468[a] DU145[b] OCI-AML-2[c]
27 h graphic file with name nihms326591t62.jpg     17 ± 4     37 ± 12     36 ± 13
27 kd graphic file with name nihms326591t63.jpg > 100 > 100 > 100
27 kg graphic file with name nihms326591t64.jpg     95 ± 9 > 100 > 100
27 ng graphic file with name nihms326591t65.jpg     33 ± 16     94 ± 7     58 ± 14
27 nh graphic file with name nihms326591t66.jpg > 100 > 100 > 100
[a]

MDA-MB-468: breast cancer.

[b]

DU145: prostate cancer.

[c]

OCI-AML-2: acute myeloid leukemia.