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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: Neuroscience. 2011 Aug 16;194:160–169. doi: 10.1016/j.neuroscience.2011.08.022

Fig. 3. Systemic treatment with tizanidine or isoflurane anesthesia suppress Hoffmann reflex activity in animals with spinal ischemic injury.

Fig. 3

A, B: In comparison to control naive animals (A), rats with spinal ischemic injury, which showed increase in stretch reflex activity, had significantly increased H-wave response after electrical stimulation of the tibial nerve (see Table 1 for details).

C: In animals with spinal ischemic injury, systemic administration of tizanidine (1 mg kg-1; i.p.) effectively suppressed otherwise increased H-wave response (Table 1).

D, E: In animals with spinal ischemic injury but without tizanidine treatment isoflurane anesthesia (2%) lead to a potent reduction in H-reflex amplitude (Table 1).