Fig. 10.

Model fit to osmotic transient data (38). The basic parameter set was adjusted by increasing d_im to 3 μm and decreasing collagen and interstitial matrix quantities (Q_col and Q_im) to 0.021 and 5.4 × 10⁻⁴ g/ml, respectively, to account for edema present in the experimental preparation. Flow was 13 ml/min, p_a was 24 mmHg, p_isf was 5.45 mmHg, and Ω_a was 1.33 mmHg·min·ml⁻¹. A: fit of model (solid line) to organ weight data with 20 mM NaCl as the osmotic agent. B: fit to transient in the same heart with 0.5 mM albumin as the osmotic agent. (The small sharp rise in weight at time = 4 min is due to the increased viscosity of the albumin-containing solution.)