Table 3. Components of the post-translational machinery present in PML NBs.
| Type of modification | Protein name | Uniprot accession number | effect |
| Acetylation | CBP | Q92793 | + |
| p300 | Q09472 | + | |
| TIP60 | Q92993 | + | |
| HDAC1 | Q13547 | − | |
| HDAC2 | Q92769 | − | |
| HDAC3 | O15379 | − | |
| HDAC7 | Q8WUI4 | − | |
| SIRT1 | Q96EB6 | − | |
| Methylation | PRMT1 | Q99873 | + |
| EZH2 | Q15910 | + | |
| Phosphorylation | CK1 | P48729 | + |
| CK2 | P68400 | + | |
| MNK2b | Q9HBH9 | + | |
| p38 | Q16539 | + | |
| IKKe | Q14164 | + | |
| ATR | Q13535 | + | |
| ATM | Q13315 | + | |
| mTOR | P42345 | + | |
| STK6 | O14965 | + | |
| CHK2 | O96017 | + | |
| HIPK1 | Q86Z02 | + | |
| HIPK2 | Q9H2X6 | + | |
| HIPK3 | Q9H422 | + | |
| ZIPK | O43293 | + | |
| SUMOylation | SUMO-1 | P63165 | |
| SUMO-2 | P61956 | ||
| SUMO-3 | P55854 | ||
| UBA2 | Q9UBT2 | + | |
| UBC9 | P63279 | + | |
| PIASy | Q8N2W9 | + | |
| RANBP2 | P49792 | + | |
| MMS21 | Q96MF7 | + | |
| SENP1 | Q9P0U3 | − | |
| SENP2 | Q9HC62 | − | |
| SENP5 | Q96HI0 | − | |
| Ubiquitination | TOPORS | Q9NS56 | + |
| BRCA1 | P38398 | + | |
| RNF6 | Q9Y252 | + | |
| RBCK1 | Q9BYM8 | + | |
| MDM2 | Q00987 | + | |
| E6AP | Q05086 | + | |
| FBX3/SCF | Q9UK99 | + | |
| CULLIN1 | Q13616 | + | |
| SKP1 | P63208 | + | |
| PLZF | Q05516 | + | |
| UBP7 | Q93009 | − |
Enzymes involved in post-translational modifications of proteins and described as associated with PML Nuclear Bodies, according to Van Damme et al. [34]. These proteins represent about 30% of all proteins associated with PML NBs, highlighting a potential integrative role of PML NBs in post-translational maturation of nuclear proteins. Proteins followed by a + sign are mainly involved in the transfer of post-translational moieties to protein substrates (e.g. kinases), whereas those with a − sign are associated to protein demodification (e.g. phosphatases). Uniprot accession IDs are in italic.