Table 2. Antiretroviral therapy input parameters for model-based analyses.
Variable | Base Case Value | Monthly Cost (US$) | Reference |
Antiretroviral therapy efficacy: % HIV RNA suppression at 24 weeks, mean increase in CD4 cell count at 48 weeks | |||
First line | 86.0 | 1,430 | [19], [25], [30] |
190 cells/µl | |||
Second line | 73.3 | 2,050 | [21], [22], [30] |
110 cells/µl | |||
Third line | 61.3 | 2,040 | [21], [22], [30] |
121 cells/µl | |||
Fourth line | 64.5 | 2,630 | [20], [30] |
102 cells/µl* | |||
Fifth line | 40.0 | 4,000 | [23], [24], [30] |
121 cells/µl | |||
Sixth line | 15.0 | 1,740 | [24], [30] |
45 cells/µl |
*At 24 weeks.