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. 2011 Oct 12;6(10):e25131. doi: 10.1371/journal.pone.0025131

Figure 1. Genomic organization of armed CRAd and control viruses.

Figure 1

Adwt300, is the wild- type Ad5 virus. Ad-ΔE1-TIMP2 is an E1-, E3-deleted replication-deficient Ad5 vector which expresses TIMP2 under the control of the CMV promoter in E1. Ad5/3-CXCR4 is an unarmed CRAd with a CXCR4 promoter in E1 to limit viral replication to the cancer cells in conjunction with a Ad5/3 modified fiber that contains the shaft and tail of Ad5 fiber and the Ad3 fiber knob. Ad5/3-CXCR4-TIMP2 is a CRAd with the CXCR4 promoter in E1, armed with TIMP2 in the E3B region and the aforementioned F5/3 modified fiber.