Table 2.
Frequency of Selected Resistance Mutations in the Reverse Transcriptase and Protease Genes Among Treatment Naive Patients Initiating ART Between January 2000 and September 2007 Who Underwent Genotypic Testing (n = 64)
| Mutation | No. (%) of patients |
|---|---|
| NRTI resistance | |
| M41L | 8 (10.5) |
| A62V | 1 (1.3) |
| K65R | 8 (10.5) |
| D67N | 11 (14.5) |
| K70R/E | 14 (18.4) |
| L74V | 3 (4.0) |
| V75I | 1 (1.3) |
| F77L | 0 (0) |
| Y115F/Y | 0 (0) |
| F116Y | 0 (0) |
| Q151M | 0 (0) |
| M184V/I | 50 (65.8) |
| L210W | 1 (1.3) |
| T215F | 12 (15.8) |
| K219Q/E/N/R | 5 (6.6) |
| Total NRTI resistance mutations | 114 |
| NNRTI resistance | |
| L100I | 4 (5.3) |
| K103N | 45 (59.2) |
| V106A/M | 2 (2.6) |
| V108I | 8 (10.5) |
| Y181C/I | 8 (10.5) |
| Y188C/L | 8 (10.5) |
| G190A/S | 7 (9.2) |
| P225H | 21 (27.6) |
| Total NNRTI resistance mutations | 103 |
| PI resistance | |
| D30N | 2 (2.6) |
| V32I | 1 (1.3) |
| L33F/I | 1 (1.3) |
| M46I/L | 1 (1.3) |
| I47V/A | 1 (1.3) |
| G48V | 0 (0) |
| I50V | 0 (0) |
| I54M/L | 1 (1.3) |
| L76V | 0 (0) |
| V82A/T/F/S | 0 (0) |
| I84V | 0 (0) |
| N88S | 1 (1.3) |
| L90M | 0 (0) |
| Total PI resistance mutations | 8 |