Figure 1. The relationship between infecting viral sequences and peptide amino-acid sequences.

(A) Amino acid distances between infecting viral sequences and ELISpot peptide reagent sequences. The median amino acid distance for each peptide set is represented by a solid line. Differences were tested for significance by one way ANOVA test and Dunn's test. (B) Predicted 9mer epitope coverage of two current candidate vaccine peptide sequences (C_Du422 and C_CH) and consensus clades A, B, and D peptide sequences. For each peptide set, the values shown in a solid bar are exact matches while the open bars show coverage when mismatched by 1 amino acid. Analysis was performed using the p17p24p2 Gag peptides from 39 participants.