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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Bone Miner Metab. 2011 Jun 17;30(1):19–30. doi: 10.1007/s00774-011-0288-2

Fig. 3.

Fig. 3

PD173074 inhibits expression of Dmp1, Ank, Slc20a1, and Enpp1 in mouse calvaria in organ culture. Calvariae isolated from wild type embryos at 18.5 days post-gestation were maintained in organ culture and treated with the selective FGF receptor inhibitor PD173074 at 1 μM for 24 h. Expression of mineralization-related genes, Dmp1, Ank, Mgp, Slc20a1, and Enpp1 was examined by real-time PCR. Real-time PCR was done in triplicate for each calvaria sample. Data represent means ± standard deviations of 3 control calvariae and 4 calvariae treated with PD173074. The figure presents data from one of two experiments with similar results. *p<0.05, **p<0.01, ***p<0.001.