Table 1.
Baseline characteristics
| Variable | Category* | Non-FISH | FISH | p- value | Standard Risk | High Risk | p- value |
|---|---|---|---|---|---|---|---|
| Total patients (n) | 319 | 126 | -- | 105 | 21 | -- | |
| Treatment | RD | 164 (51.4) | 59 (46.8) | 0.401 | 47 (44.8) | 12 (57.1) | 0.345 |
| Age (years) | Median (Q1, Q3) | 66 (59, 73) | 62 (55, 69) | 0.001 | 62 (55, 69) | 63 (56, 67) | 0.878 |
| Gender | Male | 182 (57.1) | 71 (56.3) | 0.916 | 59 (56.2) | 12 (57.1) | 1.000 |
| Race | White | 267 (83.7) | 114 (90.5) | 0.073 | 96 (91.4) | 18 (85.7) | 0.420 |
| ISS | Stage I | 85 (28.5) | 53 (44.2) | 0.004 | 46 (46.0) | 7 (35.0) | 0.663 |
| Stage II | 127 (42.6) | 46 (38.3) | 37 (37.0) | 9 (45.0) | |||
| Stage III | 86 (28.9) | 21 (17.5) | 17 (17.0) | 4 (20.0) | |||
| Unknown/Missing | 21 | 6 | 5 | 1 | |||
| ECOG PS | 1 or 2 | 178 (55.8) | 58 (46.0) | 0.073 | 47 (44.8) | 11 (52.4) | 0.633 |
| Bone Disease | Yes | 197 (61.8) | 79 (62.7) | 0.914 | 68 (64.8) | 11 (52.4) | 0.327 |
| Beta-2 Microglobulin (mg/l) | Median (Q1, Q3) | 3.9 (2.6, 6.1) | 3.3 (2.5, 4.6) | 0.010 | 3.2 (2.4, 4.6) | 3.8 (2.7, 4.8) | 0.287 |
| Freq. of Missing | 8 | 1 | 0 | 1 | |||
| C-reactive protein (mg/l) | Median (Q1, Q3) | 6 (3, 17) | 5 (2, 11) | 0.019 | 5 (2, 11) | 5 (2, 9) | 0.736 |
| Freq. of Missing | 44 | 5 | 1 | 4 | |||
| Serum M Spike (g/l) | Median (Q1, Q3) | 31 (18, 44) | 32 (21, 48) | 0.161 | 31 (19, 45) | 46 (30, 52) | 0.030 |
| Freq. of Missing | 26 | 7 | 7 | 0 | |||
| Albumin (g/l) | Median (Q1, Q3) | 35 (30, 40) | 37 (33, 40) | 0.038 | 37 (35, 40) | 32 (28, 39) | 0.006 |
| Freq. of Missing | 13 | 5 | 5 | 0 | |||
| Lactate dehydrogenase (u/l) | Median (Q1, Q3) | 159 (128, 208) | 154 (119, 209) | 0.455 | Median (Q1, Q3) | 159 (128, 208) | 0217 |
| Freq. of Missing | 24 | 4 | 3 | 1 | |||
| Calcium (mmol/l) | Median (Q1, Q3) | 2.33 (2.2, 2.45) | 2.3 (2.23,2.4) | 0.439 | 2.3 (2.23,2.4) | 2.25 (2.2,2.38) | 0.265 |
| Freq. of Missing | 1 | 0 | 0 | 0 | |||
| Creatinine (μmol/l) | Median (Q1, Q3) | 972 (796, 1238) | 884 (796, 1061) | 0.017 | 884 (707, 1061) | 972 (884, 1326) | 0.025 |
| Haemoglobin (g/l) | Median (Q1, Q3) | 108 (95, 122) | 115 (102, 125) | 0.003 | 116 (105, 126) | 102 (99, 118) | 0.019 |
*
Data are number (%) unless otherwise noted. Missing values are excluded from calculations of percentages or medians
ISS, International Staging System; ECOG PS, Eastern Cooperative Oncology Group performance status.