Table 4. Relative risk (RR) of colorectal cancer by molecular features according to statin use.
| Molecular Marker (no. of cases) | Nonusers | Current use | P for heterogeneity‡ |
|---|---|---|---|
| All† | |||
| No. of cases | 779 | 108 | |
| Age-adjusted RR | 1.00 | 0.87 (0.71 to 1.07) | |
| Multivariate-adjusted RR* | 1.00 | 0.92 (0.74 to 1.13) | |
| KRAS | 0.06 | ||
| Mutated cancer | |||
| No. of cases | 276 | 47 | |
| Age-adjusted RR | 1.00 | 1.16 (0.84 to 1.60) | |
| Multivariate-adjusted RR* | 1.00 | 1.20 (0.87 to 1.67) | |
| Wildtype cancer | |||
| No. of cases | 462 | 58 | |
| Age-adjusted RR | 1.00 | 0.76 (0.57 to 1.00) | |
| Multivariate-adjusted RR* | 1.00 | 0.80 (0.60 to 1.06) | |
| PTGS2 (COX-2) | 0.40 | ||
| Positive | |||
| No. of cases | 343 | 40 | |
| Age-adjusted RR | 1.00 | 0.90 (0.64 to 1.26) | |
| Multivariate-adjusted RR* | 1.00 | 0.94 (0.67 to 1.33) | |
| Negative | |||
| No. of cases | 211 | 17 | |
| Age-adjusted RR | 1.00 | 0.70 (0.42 to 1.16) | |
| Multivariate-adjusted RR* | 1.00 | 0.73 (0.44 to 1.21) | |
| MSI | 0.50 | ||
| MSI-high | |||
| No. of cases | 109 | 15 | |
| Age-adjusted RR | 1.00 | 0.77 (0.44 to 1.33) | |
| Multivariate-adjusted RR* | 1.00 | 0.80 (0.46 to 1.39) | |
| MSI-low/MSS | |||
| No. of cases | 607 | 85 | |
| Age-adjusted RR | 1.00 | 0.93 (0.74 to 1.18) | |
| Multivariate-adjusted RR* | 1.00 | 0.98 (0.77 to 1.24) | |
| CIMP | 0.83 | ||
| CIMP-high | |||
| No. of cases | 119 | 22 | |
| Age-adjusted RR | 1.00 | 0.98 (0.62 to 1.57) | |
| Multivariate-adjusted RR | 1.00 | 1.01 (0.63 to 1.62) | |
| CIMP-low/CIMP-0 | |||
| No. of cases | 590 | 81 | |
| Age-adjusted RR | 1.00 | 0.91 (0.71 to 1.15) | |
| Multivariate-adjusted RR | 1.00 | 0.95 (0.75 to 1.22) |
Adjusted for age, calendar year, study, pack-years of smoking before age 30 (never smoker, 1-4 pack-years, 5-10 pack-years, and ≥ 11 pack-years of smoking), aspirin dose (never, past, current use 1-2, 3-5, 6-14, ≥15 tablets/wk), height (continuous), BMI (<23, 23-<25, 25-<28, 28-<30, ≥30 kg/m2 in the NHS; <23, 23-<25, 25-<30, 30-<35, ≥35kg/m2 in the HPFS), family history of colorectal cancer in parents and siblings (yes, no), history of endoscopy (yes, no), red meat intake (quintiles), alcohol intake (never, 0.1-9.9 g/d, 10-14.9 g/d, 15-29.9 g/d, ≥30 g/d), and total energy intake (continuous)
Among cases with available tissue for analysis of molecular markers
For multivariate-adjusted RRs
MSI, microsatellite instability; MSS, microsatellite stability.