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Caspase-8-FLIP complex blocks RIPK-dependent necrosis, although the precise mechanism behind this inhibition is still unknown. RIPK1 and RIPK3, as well as upstream deubiquitinase CYLD, are caspase-8 cleavage targets, suggesting that cleavage of any of these proteins might be critical for necrosis inhibition. However, as little is known about what is downstream RIPK1/RIPK3 activation, other targets for caspase-8 may yet be implicated.
