Table 1.
Sociodemographic and clinical characteristics of sample (N=340) by incident use of second generation antipsychotics associated with weight gain.
| Variable | Incident Users (N=36) | Controls (N=304) | Total Sample (N=340) |
|---|---|---|---|
| N (%) | |||
| Gender: Female | 18 (50%) | 190 (63%) | 208 (61%) |
| Race | |||
| White | 31 (86%) | 281 (92%) | 312 (92%) |
| Black | 1 (3%) | 7 (2%) | 8 (2%) |
| Asian | 1 (3%) | 3 (1%) | 4 (1%) |
| Unknown | 4 (15%) | 5 (2%) | 9 (0.3%) |
| Other | 1 (3%) | 6 (2%) | 7 (2%) |
| Ethnicity: Hispanic or Latino | 0 | 5 (2%) | 5 (1%) |
| Primary Psychiatric Chart Diagnosis | |||
| Bipolar I | 10 (28%) | 104 (34%) | 114 (34%) |
| Bipolar II | 5 (14%) | 55 (18%) | 60 (18%) |
| Bipolar NOS | 3 (8%) | 37 (12%) | 40 (12%) |
| Major Depressive Disorder | 8 (22%) | 28 (9%) | 36 (11%) |
| Schizoaffective | 10 (28%) | 80 (26%) | 90 (26%) |
| Psychotropic Medications | |||
| Lithium† | 3 (8%) | 79 (26%) | 82 (24%) |
| Valproic acid derivatives | 6 (17%) | 46 (15%) | 52 (15%) |
| Lamotrigine | 3 (8%) | 51 (17%) | 54 (16%) |
| Carbamazepine | 0 | 6 (2%) | 6 (2%) |
| FGA | 10 (28%) | 46 (15%) | 56 (16%) |
| SGA | 13 (36%) | 159 (52%) | 172 (51%) |
| Antidepressant | 17 (47%) | 177 (58%) | 194 (57%) |
| Benzodiazepine | 8 (22%) | 108 (36%) | 116 (34%) |
| Clinical features | |||
| Psychosis‡ | 13 (36%) | 45 (15%) | 58 (17%) |
| Mania† | 5 (14%) | 13 (4%) | 18 (5%) |
| Depression | 9 (25%) | 57 (19%) | 66 (19%) |
| Suicidal ideation | 1 (3%) | 20 (7%) | 21 (6%) |
| Active substance abuse | 6 (17%) | 22 (7%) | 28 (8%) |
| Inpatient Setting‡ | 14 (39%) | 44 (15%) | 58 (17%) |
| Insurance | |||
| Public | 18 (50%) | 168 (55%) | 186 (55%) |
| Private | 18 (50%) | 131 (43%) | 149 (44%) |
| None | 0 | 5 (2%) | 5 (1%) |
| Marital Status | |||
| Married† | 4 (11%) | 92 (30%) | 96 (28%) |
| Divorced/Separated | 9 (25%) | 51 (17%) | 60 (17%) |
| Single | 22 (61%) | 149 (49%) | 171 (50%) |
| Widow | 1 (3%) | 11 (4%) | 12 (4%) |
| Unknown | 0 | 1 (0.3%) | 1 (0.3%) |
| Medical Diagnosis or Treatment | |||
| Diabetes mellitus | 3 (8%) | 37 (12%) | 40 (12%) |
| Hypertension | 5 (14%) | 72 (24%) | 77 (23%) |
| Obesity | 17 (47%) | 125 (41%) | 142 (48%) |
| Mean (SD) | |||
| Age | 41.3 (15.5) | 47.0 (15.9) | 46.6 (15.9) |
| Weight (kg) | 90.2 (25.5) | 88.5 (23.2) | 88.7 (23.5) |
| Body Mass Index (kg/m2) | 30.9 (7.5) | 30.8 (8.0) | 30.8 (7.9) |
†
p< 0.05
‡
p< 0.01
FGA = First generation antipsychotic, NOS=Not Otherwise Specified, SD = Standard deviation, SGA = Second generation antipsychotic