Table III.

Relative Bias and root mean square error (RMSE) in % evaluated from 1000 simulated data sets with M_base under H₀ for the volume of distribution (V/F), its interindividual variance ( ${\omega }_{V/F}^2$) and the residual error parameter (b) for the N=40/n=4, N=80/n=2, N=100/n=4,1 and N=200/n=4 designs and from 1000 simulated data sets with M_mult under H₁ for V/F, β₁, β₂, ${\omega }_{V/F}^2$ and b for the N=40/n=4, N=80/n=2 and N=100/n=4,1 designs, using estimates from SAEM and FOCE-I when available in (8)

	Parameter	N=40/n=4		N=80/n=2	N=100/n=4,1	N=200/n=4
		SAEM	FOCE-I	SAEM	SAEM	SAEM	FOCE-I
MbaseunderH0
Biais (%)	V/F	0.23	2.9	0.04	0.62	0.08	1.4
	${\omega }_{V/F}^2$	−2.8	−0.6	0.2	−4.2	−0.8	0.7
	b	−0.3	−1.9	−3.8	−0.9	0.008	−1.8
RMSE (%)	V/F	8.6	9.5	8.5	11.8	3.8	11.1
	ωV/F	28.1	28.9	27.8	38.5	13.4	13.3
	b	8.8	10.3	15.8	12.4	4.0	4.8
MmultunderH1
Biais (%)	V/F	4.1	6.7	3.9	5.1
	β1	−1.0	−0.8	−2.5	−1.4
	β2	−1.0	−1.0	−1.8	−1.3
	ωV/F	−7.5	−5.2	−1.3	−7.1
	b	−0.6	−2.2	−3.5	−0.02
RMSE (%)	V/F	17.9	19.2	15.0	19.9
	β1	19.9	20.0	15.3	18.1
	β2	21.7	21.7	16.5	21.3
	ωV/F	29.7	29.6	26.7	39.1
	b	9.22	10.1	16.8	13.0

With FOCE-I, convergence was achieved and thus estimates were obtained from 969 and 950 data sets under H₀ and H₁ respectively for N=40/n=4 and 978 data sets under H₀ for N=200/n=4