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Single channel current traces of RyR1 modified by various alanine scanning IpTxa mutants. (a) Single channel current traces of skeletal RyR1 activated in the presence of 30 nM wild-type or various mutant IpTxa (cis side) at −30 mV holding potential. Single channel opening is shown as a downward deflection. (b) The plots of Psubstate of RyR1 versus concentration of IpTxa are shown. The data points are means ± SE from 3–5 independent experiments.
