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DNase treatment abrogates E2-induced changes in B cell development in R4A Tg mice. Administration of DNase resulted in reversal of E2-induced increase in MZ B cells (A) and transitional B cells (B). However, HI DNase did not affect E2-induced changes in MZ and transitional B cells. MZ B cells were identified as CD21highCD23negCD24low, and transitional B cells were identified as CD21lowCD24high (T1) and CD21highCD24hgh (T2). Five mice were used in each group.
