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. Author manuscript; available in PMC: 2011 Oct 13.
Published in final edited form as: J Immunol. 2011 Mar 28;186(9):5304–5312. doi: 10.4049/jimmunol.1000224

FIGURE 5.

FIGURE 5

Serum from E2-treated, but not E2 plus DNase-treated R4A Tg mice leads to glomerular IgG deposition in SCID mice. SCID mice were injected i.p. with 100 μl serum from P-, E2-, E2 plus DNase-, or E2 plus HI DNase-treated R4A Tg mice. Mice were sacrificed 24 h later, and the kidneys were stained for IgG deposition (A). The IgG-positive glomeruli were counted in three different microscopic fields for each section. The average number of IgG-positive glomeruli in three individual mice in each group is represented (B). Serum from E2-treated, but not E2 plus DNase-treated R4A Tg mice resulted in glomerular deposition. A representative section from each group is shown at original magnification ×20. IgG from E2-treated R4A Tg mice deposits in kidneys; however, IgG from E2 plus DNase-treated mice does not deposit in glomeruli. HI DNase does not prevent IgG deposition in E2-treated R4A Tg mice.