TABLE 1.
Biotin status on d 0 of participants in Studies 1 and 21
| Indicator of biotin status | Normal range1 | Study 12 | Normal at d 0, n | Study 22 | Normal at d 0, n | P value3 |
| Lymphocyte PCC activity, pmol ·min−1 · mg protein−1 | 320–760 | 411 ± 104 | 4 | 478 ± 107 | 6 | >0.05 |
| Plasma concentration of 3HIA-carnitine, μmol/L | 0.005–0.018 | 0.009 ± 0.003 | 5 | 0.014 ± 0.004 | 6 | 0.008 |
| Urinary excretion of 3HIA-carnitine, mmol/mol creatinine | 0.06–0.16 | 0.12 ± 0.03 | 5 | 0.13 ± 0.04 | 6 | >0.05 |
| Urinary excretion of 3HIA, mmol/mol creatinine | 3.3–12.0 | 6.2 ± 2.5 | 5 | 13.5 ± 11.0 | 6 | >0.05 |
1
10th and 90th percentiles used as range limits for each indicator. PCC: calculated from 18 individuals; plasma 3HIA-carnitine: calculated from 51 individuals; urinary 3HIA-carnitine: calculated from 80 individuals; urinary 3HIA: calculated from 80 individuals. 3HIA, 3-hydroxyisovaleric acid; 3HIA-carnitine, 3-hydroxyisovaleryl carnitine; PCC, propionyl-CoA carboxylase.
2
Values are mean ± SD, = 5 (Study 1) or 7 (Study 2).
3
Determined by U test.