Table 2.

Comparison of placental histologic lesions among deliveries complicated by placental abruption in the presence and absence of a maternal thrombophilia

Histologic lesions	Thrombophilia		Adjusted odds ratio (95% CI)	P-value
	Present (%) (n=85)	Absent (%) (n=50)
Chorioamnionitis (n=46)	35.3	32.0	0.7 (0.2, 2.2)	0.539
Funisitis (n=28)	24.7	14.0	4.1 (1.0, 17.1)	0.055
Acute deciduitis (n=13)	7.1	14.0	0.2 (0.1, 0.7)	0.013
Meconium stained membranes (n=8)	7.1	4.0	7.7 (2.4, 127.8)	0.015
Villous hemorrhage (n=11)	5.9	12.0	0.3 (0.1, 1.5)	0.151
Villous edema (n=13)	9.4	10.0	2.0 (0.4, 9.3)	0.375
Acute villitis (n=3)	2.4	2.0	1.1 (0.1, 20.2)	0.950
Chronic deciduitis (n=39)	23.5	38.0	0.6 (0.2, 1.7)	0.342
Decidual necrosis (n=5)	4.7	2.0	20.8 (3.1, 394)	0.023
Decidual vasculopathy (n=14)‡	8.2	14.0	0.2 (0.03, 1.1)	0.069
Placental infarction (n=42)	28.2	36.0	0.4 (0.2, 1.1)	0.064
Recent infarction (n=14)	16.7	55.6	1.0 (0.3, 3.5)	0.998
Old and/or recent infarction (n=28)	83.3	44.4	15.5 (2.6, 91.3)	0.003
Infarctions <25% (n=30)	62.5	83.3	0.3 (0.1, 0.9)	0.033
Infarctions ≥25% (n=12)	37.5	16.7	1.0 (0.2, 5.2)	0.975
Advanced villous maturation (n=19)	15.3	12.0	2.5 (0.6, 10.7)	0.201
Villous dysmaturity (n=48)	29.4	46.0	0.5 (0.2, 1.3)	0.178
Hemosiderin deposition (n=4)	3.5	2.0	0.9 (0.1, 16.8)	0.923
Perivillous fibrin deposition (n=6)	4.7	4.0	2.5 (0.2, 26.2)	0.444
Intervillous thrombus (n=6)††	4.7	4.0	2.8 (0.2, 37.4)	0.443
Villitis (n=7)	3.5	8.0	0.1 (0.06, 2.1)	0.150

CI, confidence interval

Odds ratios were adjusted for hospital and year recruited to study, maternal age, parity and maternal race, and smoking in addition to every lesion listed in the table

^‡Decidual vasculopathy includes muscular thickening and/or atherosis

^††Intervillous thrombus includes lesions associated with feto-maternal hemorrhage, and large placentas of diabetes or erythroblastosis