Figure 3.

Motion affects sensor performance during a glucose-tracking study in a human subject conducted 103 days postimplantation. The continuous, fully implanted SubQ sensor (-•-) closely tracks blood glucose reference data during a glucose bolus until a significant drop in sensor signal is noted when the patient stands (circled in red). The deviation in sensor signal was attributed to postural effects (i.e., compression of the blood supply in the tissue). However, the change in patient posture could have also caused motion of the sensor relative to the surrounding tissue, triggering changes in tissue–sensor contact and/or mixing of localized glucose concentration in capsule exudate. Figure adapted from Gilligan and colleagues.¹⁶