Table 4.
Lipid profile: concentrations and ratios, by MS status and particle size phenotype (N = 185)
No SM (N = 72) |
SM (N = 113) |
|||||
---|---|---|---|---|---|---|
Phenotype A (> 260 Å) |
Phenotype B (≤ 260 Å) |
p-value | Phenotype A (> 260 Å) |
Phenotype B (≤ 260 Å) |
p-value | |
Plasma cholesterol (mg/dL) | 188 ± 35.9 | 245 ± 56 | 0.103 | 196.1 ± 83.6 | 227 ± 48 | 0.009* |
Plasma triglycerides (mg/dL) | 101 [70-129.3] | 282 [265-298] | 0.003* | 129 [91-195] | 245 [178-296] | > 0.001* |
LDL cholesterol (mg/dL) | 106.4 ± 31.8 | 137 ± 54 | 0.379 | 112 ± 34 | 124 ± 32 | 0.151 |
HDL cholesterol (mg/dL) | 60 [52-69] | 52 [47-56] | 0.329 | 53 [41-63] | 42 [38-52] | 0.072 |
Apo A-I (mg/dL) | 160.6 ± 22.1 | 168 ± 4.24 | 0.538 | 159.37 ± 31.7 | 158.7 ± 26.5 | 0.270 |
Apo A-II (mg/dL) | 31 [28-33] | 36.5 [35-38] | 0.069 | 32 [27-38] | 34 [30-41] | 0.934 |
Apo B (mg/dL) | 95.4 ± 23.1 | 139 ± 24.1 | 0.025* | 105.1 ± 21.4 | 122.5 ± 31.2 | 0.014* |
Lipoprotein (a) (mg/dL) | 18.6 [4.9-43] | 1.25 [1.2-1.3] | 0.005* | 14.3 [4.2-33.7] | 19.5 [12.9-47.3] | 0.844 |
Apo B/Apo A-I ratio | 0.60 ± 0.16 | 0.83 ± 0.12 | 0.050* | 0.69 ± 0.19 | 0.78 ± 0.18 | 0.023 |
Plasma cholesterol/HDL-c ratio | 3.22 ± 0.84 | 4.72 ± 0.50 | 0.016* | 3.84 ± 1.18 | 4.82 ± 1.17 | 0.001 |
Plasma triglycerides/HDL-c ratio | 1.65 [1.13-2.45] | 5.55 [4.73-6.34] | 0.003* | 2.49 [1.53-3.67] | 5.49 [3.99-6.85] | > 0.001* |
Log (TG/HDL-c) ratio | 0.20 ± 0.24 | 0.74 ± 0.08 | 0.003* | 0.38 ± 0.29 | 0.72 ± 0.19 | > 0.001* |
LDL particle size (Å) | 273.6 [271.1-274.7] | 255.25 [255-255.5] | 0.001* | 271.2 [267.7-273.7] | 259 [257.6-260] | > 0.001* |
Notes: Data are mean ± SD, and median and interquartile range. * Statistically significant differences.
p-value1: significance between phenotype MS in non-MS patients.
p-value2: significance between phenotype MS in MS patients.
p-value3: significance between MS status.