Figure 6. CED of trypan blue, SPIO and adenovirus targeting infiltrative C6 tumors.

When tumor infiltrated the white matter, iron particles are seen engulfing tumor cells. Penetration into solid tumor is limited either with SPIO (top two rows), trypan blue (A, bottom row) or adenovirus infusion (B, bottom row). Bottom row trypan blue and GFP images correspond to top row Perls stained images. (A) Iron and trypan blue distribution directly after infusion. (B) Iron and GFP distribution three days after infusion.