Figure 6. Sequence alignment of the β-propeller domains from the human integrin αV and αIIb subunits and seven sequences from five different bacteria, where seven FG-GAP consensus repeat motifs (pfam01839) were identified.

The secondary structure (β-strands of the seven blades) from the structures of αV and αIIb is shown with dark shading, while the secondary structure of the bacterial sequences, predicted by three different methods, PHD, PSIPRED and PROF (see Materials and Methods) is shown with light shading. The upper sequence shown in the alignment is the consensus Hidden Markov Model (HMM) signature sequence of the FG-GAP (pfam01839) motif, followed by the consensus sequence (designated Consensus) derived from the bacterial sequences shown in the alignment. Identical residues in the two consensus sequences are boxed.