Table 3. Gene signature predictive of ERBB2 status.
Gene Symbol | Correlation Coefficient | Gene description |
Positive Spearman correlation | ||
CRK7 (CDK12) | 0.38 | cyclin-dependent kinase 12 |
ERBB2 | 0.42 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
0.39 | ||
F2RL1 | 0.35 | coagulation factor II (thrombin) receptor-like 1 |
GRB7 | 0.43 | growth factor receptor-bound protein 7 |
IDI1 | 0.37 | isopentenyl-diphosphate delta isomerase 1 |
ITGB6 | 0.36 | integrin, beta 6 |
0.35 | ||
PERLD1 | 0.37 | post-GPI attachment to proteins 3 |
0.38 | ||
PPARBP | 0.45 | mediator complex subunit 1 |
0.39 | ||
SEC63 | 0.37 | SEC63 homolog (S. cerevisiae) |
STARD3 | 0.37 | StAR-related lipid transfer (START) domain containing 3 |
TRIM26 | 0.36 | tripartite motif-containing 26 |
Negative Spearman correlation | ||
DIRAS2 | -0.36 | DIRAS family, GTP-binding RAS-like 2 |
DUSP24 | -0.36 | serine/threonine/tyrosine interacting-like 1 |
UBTF | -0.36 | upstream binding transcription factor, RNA polymerase I |
Unknown | -0.37 | Not annotated |
Each row in the correlation coefficient column represents a probe set. Genes, within the borders of the ERBB2 amplicon are marked in bold. The list of genes is divided into genes with positive and negative (-) correlation coefficients. For detailed information on the probe sets see Table S2.