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. 2011 Oct 13;6(10):e26187. doi: 10.1371/journal.pone.0026187

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Kunze et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A and C) Gradient input in the main channel. (A) Stable NGF gradient was combined with a homogenous B27 distribution or a B27 gradient. (B and D) Linear regression fits from synapse distribution. (B) Homogenous B27 distribution disturbs NGF gradient sensing. Cortical neurons express polarized synapse distribution only when synergistic NGF/B27 gradients interplay. (C) Homogenous B27 distribution was combined with increased ∇C/C_avg NGF gradients. (D) Disturbed synapse distribution was recovered through high relative NGF gradients.