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. 2011 Oct 13;6(10):e26369. doi: 10.1371/journal.pone.0026369

Figure 1. Type II and Type III strains induce distinct transcriptional programs in chicken embryonic fibroblasts.

Figure 1

Microarray analysis of SL-29 chicken embryonic fibroblasts subjected to mock, Type II (ME49), or Type III (CEP) infection. 2 biological replicates were performed for each treatment and RNA was harvested at 24 hours post-infection. Genes shown are those identified as significantly up-regulated by SAM analysis (FDR<5% and fold change ≥1.5) either in Type III infection over Type II infection (A) or in Type II infection over Type III infection (B). For heatmap representation, probe intensities were log2-transformed and median centered by row; unsupervised hierarchical clustering was then performed (cluster numbers indicated on left). The color gradient key at top represents the color range in a log2 scale, from relative upregulation by 2-fold (yellow) and relative downregulation by 2-fold (blue).