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. 2011 Oct 13;7(10):e1002182. doi: 10.1371/journal.pcbi.1002182

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Biess et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Calcium diffusion in an aqueous solution contained in a pipette of length . (B) Calcium diffusion in a crowded dendrite with an effective diffusion constant of . A calcium transient of was initiated at . Note that the initial concentration is equal to about 600 particles per and evaluates to about 470 particles per micron for a dendrite with diameter . (C) Same settings than in (A) but with additional buffers (medium buffer concentration) and pumps. (D) Same settings than in (B) but with additional buffers (medium buffer concentration) and pumps. (E) -influx was injected at for 1 s at the location of the NMDAR in the middle of the dendritic segment as shown in the upper and middle panel. The resulting spatiotemporal -profile in the dendrite is shown in the lower panel. (F) Spatiotemporal profiles of in the dendrite for different influx frequencies at the location of the NMDAR. (G) Corresponding calcium spread in the dendrite as measured by the full width at half maximum (FWHM) of the calcium signal.

Inline graphic — (A) Calcium diffusion in an aqueous solution contained in a pipette of length . (B) Calcium diffusion in a crowded dendrite with an effective diffusion constant of . A calcium transient of was initiated at . Note that the initial concentration is equal to about 600 particles per and evaluates to about 470 particles per micron for a dendrite with diameter . (C) Same settings than in (A) but with additional buffers (medium buffer concentration) and pumps. (D) Same settings than in (B) but with additional buffers (medium buffer concentration) and pumps. (E) -influx was injected at for 1 s at the location of the NMDAR in the middle of the dendritic segment as shown in the upper and middle panel. The resulting spatiotemporal -profile in the dendrite is shown in the lower panel. (F) Spatiotemporal profiles of in the dendrite for different influx frequencies at the location of the NMDAR. (G) Corresponding calcium spread in the dendrite as measured by the full width at half maximum (FWHM) of the calcium signal.