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. 2011 Oct 13;7(10):e1002188. doi: 10.1371/journal.pcbi.1002188

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Wilson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A Distance-dependent delays in the L4 to L2/3 excitatory neuron projection. The onset of the post-synaptic conductance change (PSC) registers at the neuron after delay proportional to distance (minimum ), defined by connection speed or for excitatory (EPSC; solid line) and inhibitory (IPSC; dashed line) pre-synaptic neurons respectively. The inhibitory projection is in turn delayed by a constant temporal offset . B Geometry of the L4 to L2/3 projection. L2/3 neurons are indexed by vertical distance and horizontal location , with neurons located closer to barrel center A at , and located closer to barrel B at . This geometry constrains the PSC onset latencies given by the model in A to be hyperbolic functions of . Thus for simultaneous deflections of whiskers A and B the two synaptic inputs arising from deflection of whisker A (blue lines) and B (red lines) arrive in sequence depending on the location of the neuron . The earliest input arrives at the neuron directly above the barrel center and is excitatory. C The timecourse of the excitatory and inhibitory PSC evoked by a whisker A stimulus is shown with relative PSC onset times for neuron .

Inline graphic — A Distance-dependent delays in the L4 to L2/3 excitatory neuron projection. The onset of the post-synaptic conductance change (PSC) registers at the neuron after delay proportional to distance (minimum ), defined by connection speed or for excitatory (EPSC; solid line) and inhibitory (IPSC; dashed line) pre-synaptic neurons respectively. The inhibitory projection is in turn delayed by a constant temporal offset . B Geometry of the L4 to L2/3 projection. L2/3 neurons are indexed by vertical distance and horizontal location , with neurons located closer to barrel center A at , and located closer to barrel B at . This geometry constrains the PSC onset latencies given by the model in A to be hyperbolic functions of . Thus for simultaneous deflections of whiskers A and B the two synaptic inputs arising from deflection of whisker A (blue lines) and B (red lines) arrive in sequence depending on the location of the neuron . The earliest input arrives at the neuron directly above the barrel center and is excitatory. C The timecourse of the excitatory and inhibitory PSC evoked by a whisker A stimulus is shown with relative PSC onset times for neuron .