Table 2. Protein-coding variations shared by the vaccine strain PRV Bartha and the virulent strain PRV Becker, in comparison to the reference strain PRV Kaplan.
| Gene a | Amino acid residues found in PRV Bartha and Becker, which differ from PRV Kaplan b |
| VP22 (UL49) | G63D, A109T |
| VP13/14 (UL47) | T75M, D115E, E124D, D126Δ, 129–130(GD>EE), 133–134(GD>EE), D140G, 151–158(ASRAAAGP>V), S176P, 230–233(STAA>Δ), T658A |
| gB (UL27) | T556A |
| UL34 | M172L, G181Δ |
| VP1/2 (UL36) c | G184S, G475E, G1886–1887(GA>AP), A2110T, A2468T, 2782(+PAPPPSR)3, L2886P, L2983P, 2993–2996(GDED>Δ) |
| UL43 | A299T |
| gC (UL44) | E99K, A181V |
| UL25 | S36G, V231A |
| TK (UL23) | V284A |
| gH (UL22) | I539L |
| VP5 (UL19) | P502A |
| UL17 | R31A |
| UL15 | A158Δ, 203(+RGRGGG) |
| V18.8 (UL13) | V233F |
| OBP (UL9) | T233A |
| UL5 | A638P, M661V |
| UL3.5 | Q115Δ |
| UL3 | R42C, L61R, W104R |
| UNG (UL2) | P82A |
| ICP4 (IE180) | 69(+EA), T305P, S353G, 383–385(SSS>Δ), R747Q, S859G |
| ICP22 (US1) | 299–300(ED>Δ), D302E, G322E |
| gG (US4) | G348A |
a
Proteins are listed in order of occurrence along the genome (see Figure 3 for full list and functions).
b
Single AA residues changes are written in standard format, including the Kaplan reference strain AA, its position, and the AA residue found in the alternative protein sequence, e.g. S100P. Insertions are indicated by the AA position in Kaplan followed by “+” and the new AAs, e.g. 100(+RR). Deletions are indicated by the symbol Δ. Sequential changes are combined and shown with the Kaplan strain AA positions first, followed by the relevant Kaplan AA residues, then “>”, and finally the new alternative AA residues, e.g. 100–102(RAR>EDA).
c
Subscript on parentheses in UL36 indicates multiple copies of a repeating unit.