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. 2011 Oct 15;22(20):3812–3825. doi: 10.1091/mbc.E11-04-0328

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© 2011 He et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Dex acutely activates NHE3 in mouse intestine lacking SGK1 or NHERF2. (A) Villi were isolated from the Sgk1^flox/flox and Sgk1^flox/flox;Villin-Cre ilea and were treated ex vivo with 1 μM Dex or carrier for 15 min prior to measurement of NHE3 activity in the presence of Hoe-694. The rates of pH recovery at pH_i 6.6 are shown. (B) The rates of pH recovery at pH_i 6.6 in WT and Nherf2^−/− ilea treated with Dex for 15 min are shown. For all experiments, n = 3 mice and six villi per mouse were used. *, p < 0.01 and **, p < 0.05, compared with the control.