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. 2011 Oct 15;22(20):3861–3873. doi: 10.1091/mbc.E11-01-0080

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© 2011 Degnin et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — FGFR3 cleavage involves endosomal cathepsins. (A–E) wtFR3-V5–expressing T-Rex 293 cells treated with tet/FGF1, ± inhibitor, or DMSO (v), as indicated. Western blot of lysates probed for the V5 epitope. Arrow, cleaved FR3; asterisk, nonspecific band. Baf, 250 μM bafilomycin A₁; Chymostat, chymostatin; Cps I, cathepsin inhibitor I.