Table 3.
Perinatal outcomes in women with and without polycystic ovary syndrome (PCOS) giving birth to singleton pregnancies (1 195 123 total births) in Sweden, 1995 to 2007
| Perinatal outcomes | No of births (rate %) | Standardised absolute risk difference (%) in women with PCOS† | Crude odds ratio* (95% CI) | Adjusted odds ratio* (95% CI) | P value | |
|---|---|---|---|---|---|---|
| Women with PCOS (n=3787) | Women without PCOS (n=1 191 336) | |||||
| Stillbirth: | ||||||
| Yes | 17 (0.45) | 3896 (0.33) | — | 1.38 (0.85 to 2.22) | 0.90 (0.50 to 1.63) | 0.73 |
| No | 3770 (99.55) | 1 187 440 (99.67) | — | 1.00 | 1.00 | |
| Apgar score <7 at 5 minutes‡: | ||||||
| Yes | 71 (1.89) | 12 909 (1.10) | 0.54 | 1.74 (1.38 to 2.21) | 1.41 (1.09 to 1.83) | 0.0095 |
| No | 3680 (98.11) | 1 165 776 (98.90) | — | 1.00 | 1.00 | |
| Data missing | 19 | 8755 | — | — | — | |
| Neonatal death (0-27 days)‡: | ||||||
| Yes | 11 (0.29) | 2179 (0.18) | — | 1.59 (0.88-´to 2.88) | 1.58 (0.81 to 3.07) | 0.18 |
| No | 3759 (99.71) | 1 185 261 (99.82) | — | 1.00 | 1.00 | |
| Meconium aspiration‡: | ||||||
| Yes | 13 (0.34) | 1738 (0.15) | 0.17 | 2.36 (1.37 to 4.07) | 2.02 (1.13 to 3.61) | 0.018 |
| No | 3757 (99.66) | 1 185 702 (99.85) | — | 1.00 | 1.00 | |
| Large for gestational age: | ||||||
| Yes | 238 (6.32) | 45 421 (3.84) | 1.69 | 1.69 (1.48 to 1.93) | 1.39 (1.19 to 1.62) | <0.001 |
| No | 3526 (93.68) | 1 138 532 (96.69) | — | 1.00 | 1.00 | |
| Data missing | 23 | 7383 | — | — | — | |
| Macrosomia (birth weight ≥4500 g): | ||||||
| Yes | 194 (5.14) | 47 937 (4.04) | — | 1.29 (1.11 to 1.49) | 1.16 (0.99 to 1.36) | 0.072 |
| No | 3582 (94.86) | 1 139 030 (95.96) | — | 1.00 | 1.00 | |
| Data missing | 11 | 4369 | — | — | — | |
| Small for gestational age: | ||||||
| Yes | 89 (2.36) | 27 192 (2.30) | — | 1.03 (0.84 to 1.27) | 1.01 (0.81 to 1.27) | 0.91 |
| No | 3675 (97.64) | 1 156 761 (97.70) | — | 1.00 | 1.00 | |
| Data missing | 23 | 7383 | — | — | — | |
*Adjusted for maternal age, parity, body mass index, years of education, cigarette consumption, assisted reproductive technology, and year of delivery.
†Estimated for significantly associated outcomes.
‡Live births only.