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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Neurobiol Aging. 2011 Jul 7;33(4):825.e15–825.e24. doi: 10.1016/j.neurobiolaging.2011.05.014

Figure 1. Endogenous tau phosphorylation is decreased in Fyn knock-out mice.

Figure 1

A. Brain lysates from wild-type or Fyn homozygous knock-out mice were Western blotted for phosphorylated tau epitopes Ser202/Thr205 (AT8), Thr231 (AT180), or Thr181 (AT270) (top 3 panels) or total tau (bottom panel). B. Quantification of data in A. shows Fyn knock-out mice had significantly decreased tau phosphorylation as detected by AT8 (36%, p<0.05), AT180 (quantification of both bands: 47%, p<0.05), and AT270 (56%, p<0.001).