Figure 4. Pathogenic potential of colonic Treg TCRs.

(a) Adoptive transfer of peripheral T cells transduced with CT2 or CT6 into co-housed Rag1^−/− hosts. Non-transduced (none) or naive TCR (B8) transduced T cells were used as controls. Each line represents an individual recipient. One representative experiment is shown (summary in Supplementary Fig. 15b). (b) A representative H&E section of the descending colon is shown at 4x magnification 7–10 weeks after T cell transfer.