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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Neurochem. 2011 Sep 21;119(3):664–672. doi: 10.1111/j.1471-4159.2011.07450.x

Figure 2. 7PA2-CM derived oligomers but not monomers result in AMPAR and NMDAR endocytosis.

Figure 2

Surface proteins of cortical cultures were biotinylated and processed for immunoblots. Representative western blots of surface and total (a), GluA1; (b), GluA2; (c), GluN1; (d), GluN2B; (e), GluN2A; and (f), GABAAβ2/3 levels after treatment with Aβ monomers and oligomers from 7PA2-CM and control CHO-CM fractions. Histograms (lower panels) show quantification of surface receptors normalized to total receptor levels. Histograms show oligomers but not monomers lead to significant loss of surface NMDA and AMPA receptors (**p < 0.01; n = 4)