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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Neurochem. 2011 Sep 28;119(3):474–485. doi: 10.1111/j.1471-4159.2011.07441.x

Figure 4. Epipregnanolone sulfate increases AMPA-mEPSC frequency.

Figure 4

(A) Sample traces of AMPA-mEPSC recordings at P6 in a control PC (calibration: 20 pA, 0.5 s) and corresponding average traces (calibration: 6 pA, 8 ms). (B) Corresponding cumulative probability plots; epipregnanolone sulfate significantly decreased the inter-event interval (p < 0.01 by K–S test) but not the amplitude of these events. (C) Sample traces of AMPA-mEPSC recordings in a La3+ treated cell at P7 (calibration: 20 pA, 0.5 s) and corresponding average traces (calibration: 8 pA, 12 ms). (D) Corresponding cumulative probability plots; in the presence of La3+. (E) Time courses of AMPA-mEPSC frequency corresponding to the control and the La3+ recordings shown in A and C. (F) Summary of the effect of epipregnanolone sulfate (EpipregnanS) on AMPA-mEPSC frequency (* p < 0.05 vs. zero by Wilcoxon Signed Rank Test). In the presence of La3+ the effect of epipregnanolone sulfate was significantly reduced (Mann-Whitney test, *** p <0.05; n = 8).