Table 1. Comparison of protein abundance difference in synapse enriched fraction from hippocampus in lithium treated and non- treated animal.
Proteins that are significantly altered following chronic lithium treatment. 20 proteins were identified that were significantly altered following chronic lithium treatment. Criteria for significance were a p value cutoff of > 0.9, effect size of > ± 0.8, and log2-fold change of ± 0.8. Bold font indicates proteins whose expression is significantly affected by both lithium and valproate. Log2-fold changes greater than zero indicate increased expression in the treatment group, while values less than zero indicate decreases in expression. References are provided for proteins that have been previously implicated in relevant neurological and psychiatric diseases.
| Protein | Log2 fold change |
p value |
Disease function |
Description |
|---|---|---|---|---|
| IGSF8_MOUSE | 2.4 | 0.97 | Glioblastoma/ AD(Zhang et al. 2005) |
Implicated in neurite outgrowth and maintenance of neural networks. Overexpression is shown to inhibit glioblastoma invivo and invitro(Murdoch et al. 2003, Kolesnikova et al. 2009) |
| 1433T_RAT | 2.1 | 0.92 | Schz | Adapter protein |
| E41L3_MOUSE | 1.9 | 0.95 | Interacts with actin and spectrin and plays a role in recruitment of NMDARs to synaptic junctions(Hoy et al. 2009) |
|
| 1433F_RAT | 1.8 | 0.91 | Schz/BD | Adapter protein |
| PDE2A_RAT | 1.8 | 0.96 | Depression | Implicated in depression and elevated levels are shown in hippocampus and cerebellum on treatment of antidepressants(Esposito et al. 2009) |
| 1433E_RAT | 1.7 | 0.93 | Schz/BD | Adapter protein |
| 1433Z_RAT | 1.4 | 0.92 | Schz | Adapter protein |
| VA0D1_MOUSE | 1.4 | 0.98 | BD (Wellcome, 2007) |
ATP Synthetase |
| RIMB2_RAT | 1.2 | 0.90 | Regulation and coordination of synaptic vesicle trafficking and exocytosis(Hibino et al. 2002) |
|
| DYHC1_RAT | 1.1 | 0.97 | Motor protein | |
| GRM3_RAT | 1.0 | 0.93 | Schz | Metabotropic glutamate receptor 3 |
| QCR1_RAT | 0.8 | 0.99 | HD(Trushina & McMurray 2007) /Depression |
Level shown to be reduced in patients suffering with depression(Johnston-Wilson et al. 2000) |
| ANK3_HUMAN | 0.8 | 0.94 | BD |
Regulation of the assembly of voltage gated sodium channels |
| CAMKV_RAT | −0.8 | 0.94 | Signaling | |
| CSKI1_RAT | −0.8 | 0.92 | Forms tripartite complex of unknown function with CASK and neurexin-1 (Tabuchi et al. 2002) |
|
| CTNA2_MOUSE | −1.2 | 0.92 | BD (Wellcome, 2007)/PMN |
Regulator of synaptic remodeling and plays role in stability of dendritic spines and contacts(Abe et al. 2004) |
| RGRF1_RAT | −1.3 | 0.93 | Activation of Erk and cAMP signaling by coupling of NMDARs to Ras(Sepulveda et al. 2010) |
|
| TPIS_RAT | −1.5 | 0.98 | HD(Strand et al. 2005) | Glycolytic enzyme linked to inositol depletion during lithium treatment(Shi et al. 2005) |
| CCG8_RAT | −1.5 | 0.97 | Regulation and translocation of AMPA receptors on synaptic membranes(Rouach et al. 2005) |
Abbreviations: Alz, Alzheimer’s Disease; BD, Bipolar Disorder; HD, Huntington's Disease; PMN, progressive motor neuropathy; Schz, Schizophrenia.