Table 2.

Average Pearson's correlation coefficient of energy score with TM-score and average TM-score of selected models

Decoy sets	DFIRE	RWplus	dDFIRE	OPUS-PSP	GOAP	No. of targets
4state_reduced	−0.635 0.659	−0.606 0.667	−0.693 0.732	−0.589 0.755	−0.694 0.818	7
fisa	−0.446 0.449	−0.462 0.434	−0.461 0.454	−0.282 0.405	−0.347 0.475	4
fisa_casp3	−0.243 0.288	−0.240 0.277	−0.149 0.309	−0.095 0.270	−0.221 0.300	5
lmds	−0.118 0.333	−0.147 0.346	−0.248 0.364	−0.091 0.339	−0.146 0.339	10
lattice_ssfit	−0.094 0.247	−0.097 0.251	−0.070 0.266	−0.051 0.248	−0.058 0.248	8
hg_structal	−0.817 0.890	−0.806 0.891	−0.796 0.891	−0.752 0.891	−0.825 0.889	29
ig_structal	−0.785 0.945	−0.782 0.948	−0.766 0.948	−0.779 0.953	−0.865 0.946	61
ig_structal_hires	−0.876 0.947	−0.879 0.950	−0.844 0.946	−0.832 0.946	−0.885 0.944	20
MOULDER	−0.859 0.734	−0.840 0.745	−0.881 0.748	−0.802 0.738	−0.886 0.771	20
ROSETTA	−0.441 0.507	−0.444 0.505	−0.393 0.480	−0.343 0.506	−0.476 0.511	58
I-TASSER	−0.519 0.571	−0.488 0.577	−0.525 0.578	−0.284 0.547	−0.477 0.567	56
CASP9	−0.604 0.618	−0.585 0.609	−0.481 0.593	−0.448 0.624	−0.611 0.627	112
All average	−0.610 0.669	−0.599 0.668	−0.566 0.663	−0.500 0.670	−0.626 0.677	390
P value∗	0.010	5.0 × 10−5	1.8 × 10−10	1.8 × 10−45	—
P value†	0.042	0.036	9.2 × 10−4	0.065	—
No. of targets‡	274	273	269	268	274

Native structures are excluded from all sets. Highlighted entries are the best ones in the respective set. The first number in each cell is the Pearson correlation coefficient; the second number is the TM-score of lowest energy selected model.

^∗Two-sided P value of Student's t-test of the difference of the Pearson's correlation coefficient between GOAP and the given method.

^†Two-sided P value of Student's t-test of the difference of TM-score of top-ranked model between GOAP and the given method.

^‡Number of targets whose top-rank model has a TM-score to native >0.5.