Snapshots of simulations of PC/PS/Chol 70:20:10 in the presence of annexin. (A) Lipid and (B) protein, without protein-protein interactions (εA = 0); (C) lipid and (D) protein, with a protein-protein interaction εA = –0.68 kcal/mol. Lipid: PS, black; PC, gray; Chol, white. Protein: black hexagons on lipid matrix (gray).