Figure 5.

Mean distance to reference versus time for each unfolding simulation at 498 K. Lines have been smoothed using adjacent averaging to remove noise. The intermediate state region (0.135 to 0.15) in property space was determined from the positions of TS1 and TS2 in the free energy reaction coordinates from Fig. 4 for runs 2 and 4. It is clear that runs 2 and 4 populate this region significantly while the others pass through the intermediate more rapidly.