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The osmotic-stress and ER-stress signal-integrating pathway. ER stress and osmotic stress activate two independent signaling pathways (1 and 2), which converge on NRP-A and NRP-B expression to activate an osmotic- and ER-stress integrating pathway, also called the integrated pathway. The enhanced accumulation of membrane-associated NRPs activates a cascade to induce the expression of the nuclear transactivator, NAC6, which, in turn, promotes cell death.
