Table 2:
Association between the use and the percent maximum daily doses of different nonaspirin NSAIDs and risk of having a spontaneous abortion
| Variable | Controls n = 47 050 | Cases n = 4 705 | OR (95% CI) | |
|---|---|---|---|---|
| Crude | Adjusted* | |||
| Type of NSAID | ||||
| None | 45 837 (97.4) | 4 353 (92.5) | 1.00 | 1.00 |
| Naproxen | 435 (0.9) | 133 (2.8) | 3.22 (2.65–3.92) | 2.64 (2.13–3.28) |
| Ibuprofen | 258 (0.6) | 61 (1.3) | 2.49 (1.88–3.30) | 2.19 (1.61–2.96) |
| Rofecoxib | 152 (0.3) | 39 (0.8) | 2.70 (1.90–3.85) | 1.83 (1.24–2.70) |
| Diclofenac | 82 (0.2) | 31 (0.7) | 3.99 (2.63–6.03) | 3.09 (1.96–4.87) |
| Celocoxib | 111 (0.2) | 30 (0.6) | 2.85 (1.90–4.27) | 2.21 (1.42–3.45) |
| Other | 57 (0.1) | 32 (0.7) | 2.86 (1.93–4.23) | 2.65 (1.71–4.12) |
| Combination | 118 (0.2) | 26 (0.6) | 4.80 (3.02–7.65) | 2.64 (1.59–4.39) |
| Maximum daily dose, % | ||||
| None | 45 837 (97.4) | 4 353 (93.0) | 1.00 | 1.00 |
| 1–50 | 228 (0.5) | 59 (1.3) | 2.73 (2.05–3.64) | 2.61 (1.90–3.59) |
| 51–65 | 259 (0.6) | 56 (1.2) | 2.28 (1.70–3.05) | 1.90 (1.39–2.61) |
| 66–80 | 365 (0.8) | 120 (2.6) | 3.47 (2.81–4.27) | 2.55 (2.03–3.21) |
| ≥ 81 | 304 (0.6) | 91 (1.9) | 3.16 (2.49–4.00) | 2.55 (1.96–3.32) |
| Unknown | 57 (0.1) | 26 (0.6) | ||
Note: CI = confidence interval, NSAID = nonsteroidal anti-inflammatory drug, OR = odds ratio.
*
Odds ratios were adjusted for confounders listed in Methods.