Extracellular matrix component staining in the jejunum. Top bars illustrate staining in villi while bottom bars illustrate staining in crypts at 1, 6, 24, 48, 72, 96 and 144 h following the administration of 200 mg/kg irinotecan intraperitoneally. All control and experimental tissue were graded by a qualitative scale. The data are means + standard error; significance indicated on the graph.